Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80 low pro-tumor phenotype, including direct activation of Ccr2.
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Only TAMs that expressed full levels of Zeb1 accelerated tumor growth. Here we describe that TAMs require ZEB1 for their tumor-promoting and chemotherapy resistance functions in a mouse model of ovarian cancer. However, a role for ZEB1 in macrophages and TAMs has not been studied. ZEB1 is best known for driving an epithelial-to-mesenchymal transition (EMT) in cancer cells to promote tumor progression. However, the mechanisms that drive the pro-tumor functions of TAMs are not fully understood. Tel: +34 93 227 5400 E-mail: Īccumulation of tumor-associated macrophages (TAMs) associates with malignant progression in cancer. ‡ These authors contributed equally to this work.7 Department of Ophthalmology and Visual Sciences and Birth Defects Center, University of Louisville, Louisville, KY, USA.6 Centre d'Immunologie de Marseille-Luminy, INSERM U1104 and CNRS MR7280, Marseille, France.5 MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, and Semmelweis University 2nd Department of Pediatrics, Budapest, Hungary.4 Department of Oral Immunology, and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, KY, USA.3 CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science & Technology, and Universitat Pompeu Fabra, Barcelona, Spain.2 Department of Pathology, Hospital Clínico San Carlos, Madrid, Spain.1 Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain.
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